The ALKBH7 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ALKBH7. This antibody recognizes Human, and Mouse antigen. The ALKBH7 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Function: May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
Subunit Structure: Monomer.
Similarity: Belongs to the alkB family